Home » Compare and contrast two cell signalling pathways.

Compare and contrast two cell signalling pathways.

Nitric oxide (NO)/cyclic GMP signalling pathway
PtdIns 3-kinase signalling

Use Harvard style referencing

You will work in pairs to write a literature review that compares and contrasts two cell signaling pathways (these will be assigned to you by the lecturer). There are two facets to the review, one will assess individual student contribution through the description of a pathway (see points 1 and 2 below) and the other will asses the combined work of the pair relating to comparison of the pathways (see points 3 and 4 below). This material will later be presented in the tutorials.

As individuals you are required to:

1. Describe the mode of action of one cell signalling pathway (one page each), each student will write about a different pathway so that both pathways are covered in the article. Clearly indicate which section was written by each of you.

2. Construct a table showing the history of discovery of the pathway you wrote about, with an emphasis on the most recent discoveries (one page each), be sure to give attribution to the researchers who originally published the discoveries.

As a pair you are required to:
3. Contextualize a situation in which these pathways are known to be activated and/or repressed and discuss their relationship to one another, i.e. whether these pathways are able to interact or whether they are distinct (one page combined).
4. Draw a single figure (illustration) to summarise the pathways and relationship (if any) that exist between these pathways (one page combined).

Note: The finished assignment will later be used as the basis of an oral presentation to be given by the student pair during a tutorial. This presentation must be completed otherwise no marks for the overall assignment will be awarded.

Be sure to make critical judgments regarding the material to include since the main body of your combined report must not exceed six pages (single sided, single-spaced, 12-point font). You must therefore be very careful in selecting relevant material to include in your assignment. Title page, references, figure and table legends (and/or additional figures or tables) do not contribute to the total page count (although they must be included within the document).

Source your literature primarily from peer review journal articles, use database services such as PubMed, Web of Science or Google Scholar to find relevant articles. Use Harvard style referencing. Figures and tables should be Drawn/tabulated by yourself to highlight or summarise key aspects of
you discussion.

Your research into the topic is self directed, think of some questions to ask yourself whilst you read the literature such as: What is the purpose of the signalling pathway? How does it operate? To what extent is the pathway conserved across species? What is known about the pathway in model organisms? Were model organisms important in gaining an understanding of the pathway? What biological techniques were important in delineating the pathway? What was the timeline of
discovery? How well is the pathway understood? What are the current areas of research being pursued in regard to this pathway? Is the pathway implicated in disease? Is there a family of proteins involved in the pathway? Does the pathway exhibit different characteristics in different tissue? How well is the pathway defined? What research tools are available to study this pathway? What aspects of this pathway are shared with other signalling pathways?

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